Blood–brain barrier dysfunction in immuno-mediated neurological diseases

BKCa channel dysfunction in neurological diseases

The large conductance, Ca(2+)-activated K(+) channels (BKCa, KCa1.1) are expressed in various brain neurons where they play important roles in regulating action potential duration, firing frequency and neurotransmitter release. Membrane potential depolarization and rising levels of intracellular Ca(2+) gated BKCa channels, which in turn results in an outward K(+) flux that re/hyperpolarizes the...

orofacial manifestations of neurological diseases

چکیده ندارد.

Structural Basis of Oxidant - Mediated Barrier Dysfunction

Lum, Hazel, and Kenneth A. Roebuck. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 280: C719–C741, 2001.—Reactive oxygen species (ROS) are generated at sites of inflammation and injury, and at low levels, ROS can function as signaling molecules participating as signaling intermediates in regulation of fundamental cell activities such as cell growth and cell adaptatio...

Neural Mechanisms of Autonomic Dysfunction in Neurological Diseases

Immunological Basis of Neurological Diseases

Clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. This attitude is no longer acceptable. Surge of information and discoveries in neurosciences within the last two decades translated into therapeutic interventions which is literally life saving in some o...